Premature Lactation Glp-1 Hormone Epidemic

(Simple Explanation). Most people associate GLP-1 with injections or medications. But GLP-1 (glucagon-like peptide-1) is actually a natural hormone produced in your gut. Its job is powerful: It signals fullness to the brain.

GLP-1 medications act like the GLP-1 hormone that controls feelings of hunger and fullness. They act on receptors in both the brain and the gut. The hypothalamus in the brain regulates hunger and appetite and gets signals about when to stop eating, said de Souza.

A study found that people with the PAM gene variant, p.S539W, have a decreased sensitivity to the GLP-1 hormone. The genetic variant can interfere with the activation of hormones.