Niche Regulation Of Glp-1 Secretion

Regulation of GLP-1 secretion by ingested nutrients. After a meal, nutrients in the duodenum activate a proximal-distal neuroendocrine loop, which stimulates GLP-1 secretion from L-cells in the ileum and colon.

The regulation of GLP-1 secretion has been described both in vivo and in vitro in several animal species, but data from human cellular models are lacking. For this purpose, factors and cell-signaling pathways regulating GLP-1 secretion were investigated in the...

The regulation of GLP-1 secretion rhythm by gut microbiota is essential.Some gut microbiota metabolites promote the secretion of GLP-1. GLP-1 exerts an influence on the brain, intestine, and pancreas to improve host metabolism.

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells. J Mol Endocrinol.ShcherbinaLLindqvistAThorenFischer AHAhlqvistEZhangEFalkmerSEet al. Intestinal CART is a regulator of GIP and GLP-1 secretion and expression.

Injured gut LPS. Gluco-regulatory. GLP-1. Anti-inflammatory.Furthermore, GLP-1 secretion was modestly but rapidly increased after direct LPS stimulation of GLUTag (Figures 1L and 1M) and STC-1 EECs (Figure 1N).

Piezo1 regulates GLP-1 synthesis and secretion in primary cultured mouse L cells and isolated mouse ileum. To obtain primary L cells, we isolated cell from the ileum of IntL-Cre-mT/mG mice, in which tdTomato expression switched to EGFP expression in L cells as shown in Figure 1E .